Solvates of Dasatinib: Diversity and Isostructurality

J Pharm Sci. 2016 Apr;105(4):1489-95. doi: 10.1016/j.xphs.2016.01.024.

Abstract

A series of dasatinib crystalline forms were obtained, and a hierarchical cluster analysis of their powder X-ray diffraction patterns was performed. The resulting dendrogram implies 3 structural groups. The crystal structures of several solvates representing 2 of these groups were determined. The crystal structure analysis confirms the isostructurality of solvates within structural group I and suggests a correlation between solvent molecule size and trends in crystal structures within this group. In addition, the formation relationships in 2-solvent media between different dasatinib solvate groups were determined. The formation preference of solvates was found to follow the ranking group I > group III > group II.

Keywords: crystal structure; hydrates/solvates; powder X-ray diffractometry; solvation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Cluster Analysis
  • Crystallization
  • Dasatinib / chemistry*
  • Models, Molecular
  • Powder Diffraction
  • X-Ray Diffraction

Substances

  • Antineoplastic Agents
  • Dasatinib