Resolution of inflammation: a new therapeutic frontier

Nat Rev Drug Discov. 2016 Aug;15(8):551-67. doi: 10.1038/nrd.2016.39. Epub 2016 Mar 29.


Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success. However, insight into the pathways by which inflammation is resolved has highlighted novel opportunities to pharmacologically manipulate these processes - a strategy that might represent a complementary (and perhaps even superior) therapeutic approach. This Review discusses the state of the art in the biology of resolution of inflammation, highlighting the opportunities and challenges for translational research in this field.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / therapeutic use*
  • Disease Models, Animal
  • Humans
  • Inflammation / drug therapy*
  • Inflammation / physiopathology
  • Inflammation Mediators
  • Mice
  • Rats
  • Signal Transduction / drug effects
  • Zebrafish


  • Anti-Inflammatory Agents
  • Inflammation Mediators