An analysis of the structure of the compound biological effectiveness factor

J Radiat Res. 2016 Aug;57 Suppl 1(Suppl 1):i83-i89. doi: 10.1093/jrr/rrw022. Epub 2016 Mar 28.

Abstract

This report is an analysis of the structure of the compound biological effectiveness (CBE) factor. The value of the CBE factor previously reported was revalued for the central nervous system, skin and lung. To describe the structure, the following terms are introduced: the vascular CBE (v-CBE), intraluminal CBE (il-CBE), extraluminal CBE (el-CBE) and non-vascular CBE (nv-CBE) factors and the geometric biological factor (GBF), i.e. the contributions that are derived from the total dose to the vasculature, each dose to vasculature from the intraluminal side and the extraluminal side, the dose to the non-vascular tissue and the factor to calculate el-CBE from il-CBE, respectively. The el-CBE factor element was also introduced to relate il-CBE to el-CBE factors. A CBE factor of 0.36 for disodium mercaptoundecahydrododecaborate (BSH) for the CNS was independent of the (10)B level in the blood; however, that for p-Boron-L-phenylalanine (BPA) increased with the (10)B level ratio of the normal tissue to the blood (N/B). The CBE factor was expressed as follows: factor = 0.32 + N/B × 1.65. The factor of 0.32 at 0 of N/B was close to the CBE factor for BSH. GBFs had similar values, between BSH and BPA, 1.39 and 1.52, respectively. The structure of the CBE factor for BPA to the lung was also elucidated based on this idea. The factor is described as follows: CBE factor = 0.32 + N/B × 1.80. By this elucidation of the structure of the CBE factor, it is expected that basic and clinical research into boron neutron capture therapy will progress.

Keywords: BPA; BSH; CBE factor; dermal necrosis; radiation myelopathy; radiation pneumonitis.

MeSH terms

  • Borohydrides / chemistry
  • Boron Neutron Capture Therapy
  • Central Nervous System / radiation effects
  • Humans
  • Lung / radiation effects
  • Phenylalanine / chemistry
  • Relative Biological Effectiveness*
  • Skin / radiation effects
  • Sulfhydryl Compounds / chemistry

Substances

  • Borohydrides
  • Sulfhydryl Compounds
  • mercaptoundecahydrododecaborate
  • Phenylalanine