Is a high level of total cholesterol a risk factor for dental implants or bone grafting failure? A retrospective cohort study on 227 patients

Eur J Oral Implantol. 2016 Spring;9(1):77-84.


Purpose: This study aims to verify the effect of hypercholeresterolaemia on implant and bone augmentation failures.

Materials and methods: A retrospective cohort study was conducted on 268 sequential patients scheduled for implant and bone augmentation surgery under conscious sedation in a private practice. Total serum cholesterol (TC) levels were assessed via blood tests before surgery. Patients were divided into two groups: TC < 200 mg/dl and TC > 200 mg/dl. A 6-month post-loading follow-up was scheduled both for implants and grafts. The outcomes considered were implant failure (removal) and graft infection/failure. The effect of cholesterol on early implant and grafting failure was investigated according to a logistic regression model.

Results: Two hundred and twenty-seven patients fulfilled inclusion criteria; 139 had hypercholesterolemia. The 6-month post-loading overall implant failure rate was 6.25% at patient level (2.00% at implant level). Partial or total graft infection rate was 10.2%. High TC increased by 7.48 times the odds of the grafting failure (P = 0.047; 95% CI: -0.94 to 59.23), whilst it did not modify the odds of implant failure (P = 0.749; 95% CI: 0.28 to 2.49).

Conclusions: High total serum cholesterol levels tend to increase graft failure rates whilst it did not influence implant failures.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alveolar Ridge Augmentation / methods*
  • Bone Transplantation / methods*
  • Cholesterol / blood
  • Cohort Studies
  • Dental Implants*
  • Dental Restoration Failure*
  • Female
  • Follow-Up Studies
  • Graft Survival
  • Humans
  • Hypercholesterolemia / complications*
  • Hyperglycemia / complications
  • Male
  • Middle Aged
  • Periodontal Diseases / complications
  • Retrospective Studies
  • Risk Factors
  • Smoking
  • Surgical Wound Infection / etiology
  • Treatment Outcome
  • Young Adult


  • Dental Implants
  • Cholesterol