Recent advances in amyotrophic lateral sclerosis

J Neurol. 2016 Jun;263(6):1241-54. doi: 10.1007/s00415-016-8091-6. Epub 2016 Mar 30.


ALS is a relentlessly progressive and fatal disease, with no curative therapies available to date. Symptomatic and palliative care, provided in a multidisciplinary context, still remains the cornerstone of ALS management. However, our understanding of the molecular mechanisms underlying the disease has advanced greatly over the past years, giving new hope for the development of novel diagnostic and therapeutic approaches. Here, we have reviewed the most recent studies that have contributed to improving both clinical management and our understanding of ALS pathogenesis.

Keywords: ALS genetics; Clinical management; Motor neuron disease; Neuroimaging; Pathogenesis.

Publication types

  • Review

MeSH terms

  • Amyotrophic Lateral Sclerosis / diagnosis*
  • Amyotrophic Lateral Sclerosis / physiopathology
  • Amyotrophic Lateral Sclerosis / therapy*
  • Humans