T cell receptor signalling in the control of regulatory T cell differentiation and function

Nat Rev Immunol. 2016 Apr;16(4):220-33. doi: 10.1038/nri.2016.26.


Regulatory T cells (TReg cells), a specialized T cell lineage, have a pivotal function in the control of self tolerance and inflammatory responses. Recent studies have revealed a discrete mode of T cell receptor (TCR) signalling that regulates TReg cell differentiation, maintenance and function and that affects gene expression, metabolism, cell adhesion and migration of these cells. Here, we discuss the emerging understanding of TCR-guided differentiation of TReg cells in the context of their function in health and disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Differentiation / immunology*
  • Humans
  • Immune Tolerance / immunology
  • Lymphocyte Activation / immunology
  • Receptors, Antigen, T-Cell / immunology*
  • Self Tolerance / immunology*
  • Signal Transduction
  • T-Lymphocytes, Regulatory / immunology*


  • Receptors, Antigen, T-Cell