Risk factors for mortality in end-stage kidney disease patients under online-hemodiafiltration: three-year follow-up study

Biomarkers. 2016 Sep;21(6):544-50. doi: 10.3109/1354750X.2016.1160428. Epub 2016 Mar 30.

Abstract

The aim of this work was to evaluate the predictors of mortality in a group of end-stage kidney disease (ESRD) patients under dialysis, by performing a three-year follow-up study. From the 236 patients included in this study, 54 patients died during the three-year follow-up period. Our data showed that the risk of death was higher in patients presenting lower levels of mean cell hemoglobin concentration, transferrin, and albumin. Our study showed that poor nutritional status and an inflammatory-induced iron depleted erythropoiesis are important factors for mortality in these patients.

Keywords: End-stage kidney disease; health-related quality of life; inflammation; iron metabolism; mortality; nutritional status; online-hemodiafiltration.

MeSH terms

  • Aged
  • Biomarkers / blood
  • Female
  • Follow-Up Studies
  • Hemodiafiltration
  • Hemoglobins / metabolism
  • Humans
  • Incidence
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / mortality*
  • Kidney Failure, Chronic / therapy
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Regression Analysis
  • Risk Factors
  • Serum Albumin / metabolism
  • Transferrin / metabolism

Substances

  • Biomarkers
  • Hemoglobins
  • Serum Albumin
  • Transferrin