[Systemic therapy of metastatic renal cell carcinoma]

Dtsch Med Wochenschr. 2016 Apr;141(7):466-9. doi: 10.1055/s-0042-104594. Epub 2016 Mar 31.
[Article in German]

Abstract

In metastatic ccRCC , the treatment options in 1st line treatment are still the tyrosinkinase inhibitors (TKI) pazopanib and sunitinib, for patients with low or intermediate risk additionally IFNα/bevacizumab and for high risk patients the mTOR inhibitor temsirolimus. In 2nd line following cytokine therapy, axitinib or pazopanib and following TKI /VEGF directed therapy axitinib or everolimus may be administered. New upcoming agents in RCC are the PD1 antibody nivolumab and the multikinase inhibitor Cabozantinib, which both showed an OS advantage compared to everolimus. After marketing authorization in Europe, these agents should therefore be preferred in 2nd and 3rd line therapy. Further agents are under investigation.

MeSH terms

  • Carcinoma, Renal Cell / drug therapy*
  • Humans
  • Indoles / therapeutic use
  • Kidney Neoplasms / drug therapy*
  • Protein Kinase Inhibitors / therapeutic use*
  • Pyrimidines / therapeutic use
  • Pyrroles / therapeutic use
  • Sulfonamides / therapeutic use
  • Sunitinib

Substances

  • Indoles
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Pyrroles
  • Sulfonamides
  • pazopanib
  • Sunitinib