Myotonic dystrophy is closely linked to the gene for muscle-type creatine kinase (CKMM)

Hum Genet. 1989 Mar;81(4):308-10. doi: 10.1007/BF00283680.


We have studied genetic linkage between the gene for creatine kinase muscle type (CKMM) and the gene for myotonic dystrophy (DM). In a panel of 65 myotonic dystrophy families from Canada and the Netherlands, a maximum lod score (Zmax) of 22.8 at a recombination frequency (theta) of 0.03 was obtained. Tight linkage was also demonstrated for CKMM and the gene for apolipoprotein C2 (ApoC2). This establishes CKMM as a useful marker for myotonic dystrophy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apolipoprotein C-II
  • Apolipoproteins C / genetics
  • Chromosomes, Human, Pair 19*
  • Creatine Kinase / genetics*
  • Gene Frequency
  • Genetic Linkage*
  • Genetic Markers
  • Humans
  • Isoenzymes
  • Myotonic Dystrophy / genetics*
  • Recombination, Genetic


  • Apolipoprotein C-II
  • Apolipoproteins C
  • Genetic Markers
  • Isoenzymes
  • Creatine Kinase