Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs

Am J Psychiatry. 2016 Apr 1;173(4):429-31. doi: 10.1176/appi.ajp.2015.15121545.

Authors

Affiliation

¹ From the Departments of Neurological Surgery and of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland; the Intramural Research Program, Clinical Trials Treatment Branch, the Clinical Pharmacology and Therapeutics Research Branch, and the Cellular Neurobiology Branch, NIDA, Baltimore; and the Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

MeSH terms

Case-Control Studies
Dopaminergic Neurons / cytology
Dopaminergic Neurons / metabolism*
Humans
Induced Pluripotent Stem Cells / cytology
Induced Pluripotent Stem Cells / metabolism*
Opioid-Related Disorders / genetics*
RNA, Messenger / metabolism*
Receptors, Dopamine D2 / genetics*
Receptors, Opioid, mu / genetics
Reverse Transcriptase Polymerase Chain Reaction

Substances

DRD2 protein, human
RNA, Messenger
Receptors, Dopamine D2
Receptors, Opioid, mu

Grants and funding