The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia

Haematologica. 2016 Jul;101(7):e291-4. doi: 10.3324/haematol.2016.142794. Epub 2016 Apr 1.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Disease-Free Survival
  • Drug Resistance, Neoplasm*
  • Female
  • Humans
  • Male
  • Methotrexate / administration & dosage*
  • Neoplasm Proteins* / genetics
  • Neoplasm Proteins* / metabolism
  • Peptide Synthases* / genetics
  • Peptide Synthases* / metabolism
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / enzymology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / mortality
  • RNA Splicing*
  • Survival Rate

Substances

  • Neoplasm Proteins
  • Peptide Synthases
  • folylpolyglutamate synthetase
  • Methotrexate