Ketone Bodies Signal Opportunistic Food-Seeking Activity

Trends Endocrinol Metab. 2016 Jun;27(6):350-352. doi: 10.1016/j.tem.2016.03.014. Epub 2016 Mar 30.


Food-seeking activity at a predictable time of the day is one of the fundamental 'opportunistic behaviors' for survival. The neural and molecular basis for such anticipatory activity is not clearly understood. However, a new report shows that, after several hours of fasting, liver-derived ketone bodies have a key role in this behavior.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticipation, Psychological / physiology
  • Appetitive Behavior / physiology
  • Fasting / physiology
  • Humans
  • Ketone Bodies / metabolism*
  • Liver / metabolism


  • Ketone Bodies