Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jun;27(6):350-352.
doi: 10.1016/j.tem.2016.03.014. Epub 2016 Mar 30.

Ketone Bodies Signal Opportunistic Food-Seeking Activity

Affiliations
Free PMC article
Review

Ketone Bodies Signal Opportunistic Food-Seeking Activity

Amandine Chaix et al. Trends Endocrinol Metab. .
Free PMC article

Abstract

Food-seeking activity at a predictable time of the day is one of the fundamental 'opportunistic behaviors' for survival. The neural and molecular basis for such anticipatory activity is not clearly understood. However, a new report shows that, after several hours of fasting, liver-derived ketone bodies have a key role in this behavior.

Figures

Figure 1
Figure 1. Liver-derived and Per2 driven β-OHB is necessary for food anticipatory behavior
(a) Summary of genetic experiments showing the necessity of Per2 in the liver for FA. (b) In addition to b-OHB, other peripheral signal may be involved in transmitting food timing to the brain.

Similar articles

See all similar articles

Cited by 2 articles

Publication types

Feedback