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. 2016 Jun;27(6):350-352.
doi: 10.1016/j.tem.2016.03.014. Epub 2016 Mar 30.

Ketone Bodies Signal Opportunistic Food-Seeking Activity

Free PMC article

Ketone Bodies Signal Opportunistic Food-Seeking Activity

Amandine Chaix et al. Trends Endocrinol Metab. .
Free PMC article


Food-seeking activity at a predictable time of the day is one of the fundamental 'opportunistic behaviors' for survival. The neural and molecular basis for such anticipatory activity is not clearly understood. However, a new report shows that, after several hours of fasting, liver-derived ketone bodies have a key role in this behavior.


Figure 1
Figure 1. Liver-derived and Per2 driven β-OHB is necessary for food anticipatory behavior
(a) Summary of genetic experiments showing the necessity of Per2 in the liver for FA. (b) In addition to b-OHB, other peripheral signal may be involved in transmitting food timing to the brain.

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