The Link Between Infantile Colic and Migraine

Curr Pain Headache Rep. 2016 May;20(5):31. doi: 10.1007/s11916-016-0558-8.


Infantile colic is a self-limiting disorder of excessive infant crying or fussiness that peaks at 6 weeks of age and typically improves by 3 months of age. The etiology of infantile colic has yet to be definitively elucidated, but there is increasing research to support its relationship to migraine. The aims of this review are to present recent research investigating the connection between infantile colic and migraine. The importance of identifying this connection is useful in reducing invasive and potentially harmful investigations and to identify age appropriate pharmacologic interventions that would be safe in this population.

Keywords: Baby migraine; Infantile colic; Migraine; Pediatric migraine.

Publication types

  • Review

MeSH terms

  • Colic / complications
  • Colic / diagnosis
  • Colic / drug therapy*
  • Dicyclomine / therapeutic use*
  • Diet Therapy*
  • Humans
  • Migraine Disorders / complications
  • Migraine Disorders / diagnosis
  • Migraine Disorders / drug therapy*
  • Proton Pump Inhibitors / therapeutic use*
  • Simethicone / therapeutic use*


  • Proton Pump Inhibitors
  • Dicyclomine
  • Simethicone