Transient Deformation of Neutrophils in Kawasaki Disease

J Pediatr. 2016 Jun:173:238-241.e1. doi: 10.1016/j.jpeds.2016.02.065. Epub 2016 Mar 30.


In the treatment of Kawasaki disease, resistance to high-dose immunoglobulin intravenous (IGIV) can occur. The neutrophil morphology analyses in 17 patients revealed that transient pseudo-Pelger-Huët anomaly was more frequently detected in the IGIV-resistant group. This finding may aid the prediction of IGIV resistance.

Keywords: Coronary artery lesion; High-dose intravenous immunoglobulin; Kawasaki disease; Mucocutaneous lymph node syndrome; Pseudo-Pelger‐Huët anomaly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • Drug Resistance*
  • Female
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use*
  • Male
  • Mucocutaneous Lymph Node Syndrome / drug therapy*
  • Pelger-Huet Anomaly / complications
  • Pelger-Huet Anomaly / diagnosis*
  • Retrospective Studies


  • Immunoglobulins, Intravenous