Engineering virus-like particles as vaccine platforms

Curr Opin Virol. 2016 Jun:18:44-9. doi: 10.1016/j.coviro.2016.03.001. Epub 2016 Mar 29.


Virus-like particles (VLPs) have been utilized as vaccine platforms to increase the immunogenicity of heterologous antigens. A variety of diverse VLP types can serve as vaccine platforms, and research has focused on engineering VLPs to improve their efficacy as vaccines, enhance their stability, and allow for more versatile display of antigens. Here, we review selected VLP vaccine platforms, highlight efforts to improve these platforms through structure-informed rational design, and point to areas of future research that will assist in these efforts.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Antigens, Viral / chemistry
  • Antigens, Viral / genetics
  • Antigens, Viral / immunology
  • Genetic Engineering / methods
  • Immunogenicity, Vaccine*
  • Vaccines, Virus-Like Particle / chemistry
  • Vaccines, Virus-Like Particle / genetics*
  • Vaccines, Virus-Like Particle / immunology*


  • Antigens, Viral
  • Vaccines, Virus-Like Particle