Miltefosine for Mucosal and Complicated Cutaneous Old World Leishmaniasis: A Case Series and Review of the Literature

Open Forum Infect Dis. 2016 Feb 1;3(1):ofw008. doi: 10.1093/ofid/ofw008. eCollection 2016 Jan.


Complicated Old World cutaneous leishmaniasis (OWCL) and Old World mucosal leishmaniasis (OWML) constitute an indication for systemic treatment. To date, there no controlled clinical studies that compare treatment options for these diseases. We compiled a case series of 24 cases successfully treated with miltefosine. We conclude that oral miltefosine is an effective treatment option for both OWCL and OWML.

Keywords: Old World leishmaniasis; complicated cutaneous leishmaniasis; miltefosine; mucosal leishmaniasis; systemic treatment.