Probing the Fifty Shades of EMT in Metastasis

Trends Cancer. 2016 Feb;2(2):65-67. doi: 10.1016/j.trecan.2016.01.001.


The involvement of epithelial-to-mesenchymal transition (EMT) in metastasis has long been under debate. Recent efforts to probe the occurrence and functional significance of EMT in clinical samples and animal models have produced exciting but sometimes conflicting findings. The diversity of EMT underlies the challenge in studying its role in metastasis.

Keywords: Epithelial-to-mesenchymal transition (EMT); cancer metastasis; in vivo tracing; plasticity.