Novel Insights into the Role of Long Noncoding RNA in Ocular Diseases

Int J Mol Sci. 2016 Mar 31;17(4):478. doi: 10.3390/ijms17040478.


Recent advances have suggested that long noncoding RNAs (lncRNAs) are differentially expressed in ocular tissues and play a critical role in the pathogenesis of different types of eye diseases. Here, we summarize the functions and mechanisms of known aberrantly-expressed lncRNAs and present a brief overview of relevant reports about lncRNAs in such ocular diseases as glaucoma, proliferative vitreoretinopathy (PVR), diabeticretinopathy (DR), and ocular tumors. We intend to highlight comprehensive studies that provide detailed data about the mechanisms of lncRNAs, their applications as diagnostic or prognostic biomarkers, and their potential therapeutic targets. Although our understanding of lncRNAs is still in its infancy, these examples may provide helpful insights into the methods by which lncRNAs interfere with ocular diseases.

Keywords: epigenetics; long noncoding RNA; ocular disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / metabolism
  • Diabetic Retinopathy / genetics
  • Diabetic Retinopathy / pathology
  • Eye Diseases / genetics
  • Eye Diseases / pathology*
  • Glaucoma / genetics
  • Glaucoma / pathology
  • Humans
  • RNA, Long Noncoding / metabolism*
  • Vitreoretinopathy, Proliferative / genetics
  • Vitreoretinopathy, Proliferative / pathology


  • Biomarkers
  • RNA, Long Noncoding