A Pharmacogenetic Study of Psoriasis Risk Variants in a Greek Population and Prediction of Responses to Anti-TNF-α and Anti-IL-12/23 Agents

Mol Diagn Ther. 2016 Jun;20(3):221-5. doi: 10.1007/s40291-016-0198-z.


Introduction: Psoriasis is a highly divergent disease with many disease phenotypes, but there are currently no established biomarkers to predict the therapeutic outcomes of systemic treatments. With the introduction of biologic therapies during the last decade and with new treatments constantly emerging, there is a great need to validate biomarkers that have been reported to be associated with treatment response, and to introduce new biomarkers of possible clinical value.

Methods: In the current study, we aimed to investigate the association of psoriasis-related polymorphisms that have previously been reported to effect the anti-tumor necrosis factor alpha (anti-TNF-α) therapies (etanercept, adalimumab, and infliximab) and anti-interleukin-12/23 (anti-IL-12/23) biologic therapy (ustekinumab) in a Greek cohort of psoriasis patients.

Results: Rs10484554 in the HLA-C gene showed an association with a good response to anti-TNF-α agents but not to ustekinumab, while rs151823 and rs26653 in the ERAP1 gene showed associations with a good response to anti-IL-12/23 therapy.

Conclusion: This study is the first in the field of pharmacogenetics in Greek psoriasis patients. Further, larger studies are required to validate our findings and replicate them in various populations.

MeSH terms

  • Alleles
  • Antibodies, Monoclonal / pharmacology
  • Antibodies, Monoclonal / therapeutic use*
  • Genetic Variation*
  • Genotype
  • Greece
  • Histocompatibility Antigens Class I / genetics
  • Humans
  • Interleukin-12 / antagonists & inhibitors*
  • Interleukin-23 / antagonists & inhibitors*
  • Pharmacogenomic Variants*
  • Polymorphism, Single Nucleotide
  • Psoriasis / drug therapy*
  • Psoriasis / genetics*
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*
  • Ustekinumab / pharmacology
  • Ustekinumab / therapeutic use


  • Antibodies, Monoclonal
  • Histocompatibility Antigens Class I
  • Interleukin-23
  • Tumor Necrosis Factor-alpha
  • Interleukin-12
  • Ustekinumab