Hepcidin in the diagnosis of iron disorders

Blood. 2016 Jun 9;127(23):2809-13. doi: 10.1182/blood-2015-12-639112. Epub 2016 Apr 4.


The discovery of the iron-regulatory hormone hepcidin in 2001 has revolutionized our understanding of iron disorders, and its measurement should advance diagnosis/treatment of these conditions. Although several assays have been developed, a gold standard is still lacking, and efforts toward harmonization are ongoing. Nevertheless, promising applications can already be glimpsed, ranging from the use of hepcidin levels for diagnosing iron-refractory iron deficiency anemia to global health applications such as guiding safe iron supplementation in developing countries with high infection burden.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers / blood
  • Blood Chemical Analysis / methods
  • Diagnostic Techniques and Procedures*
  • Hematologic Tests
  • Hepcidins / blood
  • Hepcidins / chemistry
  • Hepcidins / physiology*
  • Humans
  • Iron Metabolism Disorders / blood
  • Iron Metabolism Disorders / diagnosis*
  • Iron Metabolism Disorders / therapy


  • Biomarkers
  • Hepcidins