Animal models of post-traumatic epilepsy

J Neurosci Methods. 2016 Oct 15:272:50-55. doi: 10.1016/j.jneumeth.2016.03.023. Epub 2016 Apr 1.


Post-traumatic epilepsy (PTE) is defined as the development of unprovoked seizures in a delayed fashion after traumatic brain injury (TBI). PTE lies at the intersection of two distinct fields of study, epilepsy and neurotrauma. TBI is associated with a myriad of both focal and diffuse anatomic injuries, and an ideal animal model of epilepsy after TBI must mimic the characteristics of human PTE. The three most commonly used models of TBI are lateral fluid percussion, controlled cortical injury, and weight drop. Much of what is known about PTE has resulted from use of these models. In this review, we describe the most commonly used animal models of TBI with special attention to their advantages and disadvantages with respect to their use as a model of PTE.

Keywords: Animal models; Epilepsy; Traumatic brain injury.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Epilepsy, Post-Traumatic* / physiopathology
  • Humans