The effect of aloe vera on ischemia--Reperfusion injury of sciatic nerve in rats

Biomed Pharmacother. 2016 Apr;79:201-7. doi: 10.1016/j.biopha.2016.02.023. Epub 2016 Mar 10.


Purpose: Aloe vera is compound which has strong antioxidant and anti-inflammatory effects. We investigated the neuroprotective role of aloe vera treatment in rats with experimental sciatic nerve ischemia/reperfusion injury.

Methods: Twenty-eight male Wistar Albino rats were divided equally into 4 groups. Groups; Control group (no surgical procedure or medication), sciatic nerve ischemia/reperfusion group, sciatic nerve ischemia/reperfusion+aloe vera group and sciatic nerve ischemia/reperfusion+methylprednisolone group. Ischemia was performed by clamping the infrarenal abdominal aorta. 24 hours after ischemia, all animals were sacrificed. Sciatic nerve tissues were also examined histopathologically and biochemically.

Results: Ischemic fiber degeneration significantly decreased in the pre-treated with aloe vera and treated with methylprednisolone groups, especially in the pre-treated with aloe vera group, compared to the sciatic nerve ischemia/reperfusion group (p<0.05). A significant decrease in MDA, an increase in NRF1 level and SOD activity were observed in the groups which obtained from the AV and MP groups when compared to the sciatic nerve ischemia/reperfusion group. When all results were analysed it was seen that the aloe vera group was not statistically different compared to the MP group (p>0.05).

Conclusions: Aloe vera is effective neuroprotective against sciatic nerve ischemia/reperfusion injury via antioxidant and anti-inflammatory properties. Also aloe vera was found to be as effective as MP.

Keywords: Aloe; Ischemia; Rats; Reperfusion injury; Sciatic nerve.

MeSH terms

  • Aloe / chemistry*
  • Animals
  • Axons / drug effects
  • Axons / pathology
  • Male
  • Malondialdehyde / metabolism
  • Myelin Sheath / drug effects
  • Myelin Sheath / pathology
  • NF-kappa B / metabolism
  • Nuclear Respiratory Factor 1 / metabolism
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Rats, Wistar
  • Reperfusion Injury / drug therapy*
  • Schwann Cells / drug effects
  • Schwann Cells / metabolism
  • Schwann Cells / pathology
  • Sciatic Nerve / drug effects
  • Sciatic Nerve / pathology*
  • Superoxide Dismutase / metabolism


  • NF-kappa B
  • Nuclear Respiratory Factor 1
  • Plant Extracts
  • Malondialdehyde
  • Superoxide Dismutase