eIF4A moonlights as an off switch for TORC1

EMBO J. 2016 May 17;35(10):1013-4. doi: 10.15252/embj.201694326. Epub 2016 Apr 4.


TORC1 is actively inhibited upon amino acid withdrawal. Tsokanos et al (2016) shed light on the underlying molecular mechanism. They demonstrate that upon removal of exogenous amino acids, eIF4A inhibits TORC1 via TSC2. Thus, whereas it is well known that TORC1 regulates the translation machinery, we now know the inverse is also true.

Publication types

  • Comment

MeSH terms

  • Cytoplasm
  • Eukaryotic Initiation Factor-4A*
  • Humans
  • Mechanistic Target of Rapamycin Complex 1*


  • Mechanistic Target of Rapamycin Complex 1
  • Eukaryotic Initiation Factor-4A