Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Feb 28;387:106-113.
doi: 10.1016/j.canlet.2016.03.047. Epub 2016 Apr 1.

Hepatocellular Carcinoma: Mouse Models and the Potential Roles of Proteases

Affiliations
Review

Hepatocellular Carcinoma: Mouse Models and the Potential Roles of Proteases

James M Henderson et al. Cancer Lett. .

Abstract

Primary liver cancer is the second most common cause of mortality from cancer. The most common models of hepatocellular carcinoma, which use a chemical and/or metabolic insult, xenograft, or genetic manipulation, are discussed in this review. In the tumour microenvironment lymphocytes, fibroblasts, endothelial cells and antigen presenting cells are important determinants of cell fate. These cells make a range of proteases that modify the biological activity of other proteins, particularly extracellular matrix proteins that alter cell migration of tumour cells, fibroblasts and leucocytes, and chemokines that alter leucocyte migration. The DPP4 family of post-proline peptidase enzymes modifies cell movement and the activities of many bioactive molecules including growth factors and chemokines.

Keywords: Dipeptidyl peptidase; Fibroblast activation protein; Hepatocellular carcinoma; Mouse models.

Similar articles

See all similar articles

Cited by 3 articles

Publication types

Substances

LinkOut - more resources

Feedback