GPCR Signaling: β-arrestins Kiss and Remember

Ravi Ranjan; Pragya Gupta; Arun K Shukla

doi:10.1016/j.cub.2016.02.056

GPCR Signaling: β-arrestins Kiss and Remember

Curr Biol. 2016 Apr 4;26(7):R285-8. doi: 10.1016/j.cub.2016.02.056.

Authors

Ravi Ranjan¹, Pragya Gupta¹, Arun K Shukla²

Affiliations

¹ Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
² Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India. Electronic address: arshukla@iitk.ac.in.

PMID: 27046816
DOI: 10.1016/j.cub.2016.02.056

Abstract

β-arrestin-dependent activation of the ERK MAP kinase downstream of GPCRs typically originates from internalized receptor-β-arrestin-ERK complexes. A new study now reports that β-arrestin 2 is sufficiently 'primed' after 'kissing' the β1-adrenergic receptor to initiate ERK activation even in the absence of formation of the receptor-β-arrestin-ERK complex and receptor internalization.

Publication types

Comment

MeSH terms

Animals
Arrestins / metabolism*
Clathrin / metabolism*
Endocytosis / physiology*
Humans
Mitogen-Activated Protein Kinases / metabolism*
Receptors, G-Protein-Coupled / metabolism*
Signal Transduction*

Substances

Arrestins
Clathrin
Receptors, G-Protein-Coupled
Mitogen-Activated Protein Kinases