Mood by microbe: towards clinical translation

Genome Med. 2016 Apr 6;8(1):36. doi: 10.1186/s13073-016-0292-1.


There is a growing realization that the gut-brain axis plays a key role in maintaining brain health and the stress response. Recently, the gut microbiota has emerged as a master regulator of this axis. Thus, opportunities to exploit the microbiome to treat stress-related psychiatric disorders are materializing. Clinical validation of such strategies is now warranted.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Affect*
  • Brain / physiology
  • Depression
  • Gastrointestinal Microbiome / physiology
  • Gastrointestinal Tract / microbiology
  • Gastrointestinal Tract / physiology
  • Homeostasis
  • Humans
  • Mental Health
  • Microbiota*
  • Stress, Physiological
  • Stress, Psychological