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. 2016 Jun:126:4-10.
doi: 10.1016/j.phytochem.2016.03.013. Epub 2016 Apr 2.

Talarolutins A-D: Meroterpenoids from an endophytic fungal isolate of Talaromyces minioluteus

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Talarolutins A-D: Meroterpenoids from an endophytic fungal isolate of Talaromyces minioluteus

Amninder Kaur et al. Phytochemistry. 2016 Jun.

Abstract

Four meroterpenoids [talarolutins A-D] and one known compound [purpurquinone A] were characterized from an endophytic fungal isolate of Talaromyces minioluteus (G413), which was obtained from the leaves of the medicinal plant milk thistle [Silybum marianum (L.) Gaertn. (Asteraceae)]. The structures of talarolutins A-D were determined by the analysis of various NMR and MS techniques. The relative and absolute configuration of talarolutin A was determined by X-ray diffraction analysis. A combination of NOESY data and comparisons of ECD spectra were employed to assign the relative and absolute configuration of the other analogs. Talarolutins B-D were tested for cytotoxicity against human prostate carcinoma (PC-3) cell line, antimicrobial activity, and induction of quinone reductase; no notable bioactivity was observed in any assay.

Keywords: Asteraceae; Fungal endophyte; Meroterpenoid; Milk thistle; Silybum marianum; Talaromyces minioluteus.

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Figures

Fig.1
Fig.1
Structures of talarolutins A–D (1–4) and purpurquinone A (5).
Fig. 2
Fig. 2
ORTEP drawing of the molecular structure of 1.
Fig. 3
Fig. 3
Experimental ECD spectra of 1–4.

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