Talarolutins A-D: Meroterpenoids from an endophytic fungal isolate of Talaromyces minioluteus
- PMID: 27048854
- PMCID: PMC4861051
- DOI: 10.1016/j.phytochem.2016.03.013
Talarolutins A-D: Meroterpenoids from an endophytic fungal isolate of Talaromyces minioluteus
Abstract
Four meroterpenoids [talarolutins A-D] and one known compound [purpurquinone A] were characterized from an endophytic fungal isolate of Talaromyces minioluteus (G413), which was obtained from the leaves of the medicinal plant milk thistle [Silybum marianum (L.) Gaertn. (Asteraceae)]. The structures of talarolutins A-D were determined by the analysis of various NMR and MS techniques. The relative and absolute configuration of talarolutin A was determined by X-ray diffraction analysis. A combination of NOESY data and comparisons of ECD spectra were employed to assign the relative and absolute configuration of the other analogs. Talarolutins B-D were tested for cytotoxicity against human prostate carcinoma (PC-3) cell line, antimicrobial activity, and induction of quinone reductase; no notable bioactivity was observed in any assay.
Keywords: Asteraceae; Fungal endophyte; Meroterpenoid; Milk thistle; Silybum marianum; Talaromyces minioluteus.
Copyright © 2016 Elsevier Ltd. All rights reserved.
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