Prevalence of antineuronal antibodies in patients with encephalopathy of unknown etiology: Data from a nationwide registry in Korea

Jung-Ick Byun; Soon-Tae Lee; Keun-Hwa Jung; Jun-Sang Sunwoo; Jangsup Moon; Tae-Joon Kim; Jung-Ah Lim; Soyun Kim; Do-Yong Kim; Su-Hyun Han; Hyemin Jang; Hong Il Suh; A-Hyun Cho; Dong Wook Kim; Jung-Won Shin; Yong Seo Koo; Woo Chan Choi; Woong-Woo Lee; Nari Choi; Seongheon Kim; Hyunwoo Nam; Dae Lim Koo; Minah Kim; Byung Chan Lim; Jong-Hee Chae; Ki Joong Kim; Daejong Jeon; Kyung-Il Park; Ki-Young Jung; Manho Kim; Kon Chu; Sang Kun Lee

doi:10.1016/j.jneuroim.2016.02.002

Prevalence of antineuronal antibodies in patients with encephalopathy of unknown etiology: Data from a nationwide registry in Korea

J Neuroimmunol. 2016 Apr 15:293:34-38. doi: 10.1016/j.jneuroim.2016.02.002. Epub 2016 Feb 21.

Authors

Jung-Ick Byun¹, Soon-Tae Lee¹, Keun-Hwa Jung¹, Jun-Sang Sunwoo¹, Jangsup Moon², Tae-Joon Kim¹, Jung-Ah Lim¹, Soyun Kim³, Do-Yong Kim³, Su-Hyun Han⁴, Hyemin Jang⁵, Hong Il Suh⁶, A-Hyun Cho⁷, Dong Wook Kim⁸, Jung-Won Shin⁹, Yong Seo Koo¹⁰, Woo Chan Choi¹¹, Woong-Woo Lee¹², Nari Choi¹³, Seongheon Kim¹⁴, Hyunwoo Nam¹⁵, Dae Lim Koo¹⁵, Minah Kim¹⁶, Byung Chan Lim¹⁷, Jong-Hee Chae¹⁷, Ki Joong Kim¹⁷, Daejong Jeon³, Kyung-Il Park¹⁸, Ki-Young Jung¹, Manho Kim¹⁹, Kon Chu²⁰, Sang Kun Lee²¹

Affiliations

¹ Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea.
² Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea; Departments of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul, South Korea.
³ Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea.
⁴ Department of Neurology, Asan Medical Center, Seoul, South Korea.
⁵ Department of Neurology, Samsung Medical Center, Seoul, South Korea.
⁶ Department of Neurology, Ajou University Medical Center, Suwon, South Korea.
⁷ Department of Neurology, Catholic University of Korea Yeouido St. Mary's Hospital, Seoul, South Korea.
⁸ Department of Neurology, Konkuk University, Seoul, South Korea.
⁹ Department of Neurology, CHA University, CHA Bundang Medical Center, Seongnam, South Korea.
¹⁰ Department of Neurology, Korea University Anam Hospital, Seoul, South Korea.
¹¹ Kyungpook National University School of Medicine, Daegu, South Korea.
¹² Department of Neurology, Eulji General Hospital, Seoul, South Korea.
¹³ Department of Neurology, Soonchun Hyang University Hospital Cheonan, Cheonan, South Korea.
¹⁴ Department of Neurology, Kangwon National University Hospital, Chuncheon, South Korea.
¹⁵ Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea.
¹⁶ Department of Psychiatry, Seoul National University Hospital, Seoul, South Korea.
¹⁷ Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.
¹⁸ Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Department of Neurology, Seoul National University Hospital Healthcare System Gangnam Center, South Korea.
¹⁹ Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea; Protein Metabolism Research Center, Seoul National University College of Medicine, Seoul, South Korea.
²⁰ Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: stemcell.snu@gmail.com.
²¹ Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: sangkun2923@gmail.com.

PMID: 27049559
DOI: 10.1016/j.jneuroim.2016.02.002

Abstract

We aimed to evaluate the prevalence of antineuronal antibodies in a nationwide cohort of patients with encephalopathy of unknown etiology. We screened 1699 patients with idiopathic encephalopathy who were referred from 70 hospitals across Korea for autoimmune synaptic and classic paraneoplastic antibodies. Those with cerebellar degeneration, sensory polyneuropathy or other paraneoplastic syndromes without encephalopathy were not included in this study. One-hundred and four patients (6.12%) had antibody-associated autoimmune encephalopathy. Autoimmune synaptic antibodies were identified in 89 patients (5.24%) and classic paraneoplastic antibodies were identified in 16 patients (0.94%). The patients with antibody-associated autoimmune encephalopathy comprised a small but significant portion of the total number of patients with encephalopathy of unknown cause.

Keywords: Autoimmune; Autoimmune synaptic antibody; Classic paraneoplastic antibody; Encephalopathy; Prevalence.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Autoantibodies / blood*
Autoantibodies / cerebrospinal fluid*
Brain Diseases / epidemiology*
Brain Diseases / etiology
Brain Diseases / immunology*
Cohort Studies
Female
Humans
Intracellular Signaling Peptides and Proteins
Male
Nerve Tissue Proteins / immunology*
Prevalence
Proteins / immunology
Receptors, N-Methyl-D-Aspartate / immunology
Registries*
Republic of Korea / epidemiology

Substances

Autoantibodies
Intracellular Signaling Peptides and Proteins
LGI1 protein, human
Nerve Tissue Proteins
Proteins
Receptors, N-Methyl-D-Aspartate