Multiantigenic subunitary vaccines against tuberculosis in clinical trials: Where do we stand and where do we need to go?

Hum Vaccin Immunother. 2016 May 3;12(5):1193-5. doi: 10.1080/21645515.2015.1136760. Epub 2016 Apr 6.

Abstract

The idea of presenting this commentary is to bring attention to the current status of clinical tests from several multiantigen vaccine candidates based on proteins produced by means of genetic engineering and molecular biology approaches and to suggest how new emerging technologies (OMICs) and bioinformatics might benefit vaccine development for better control of tuberculosis.

Keywords: clinical trials; multiantigenic; tuberculosis; vaccines.

MeSH terms

  • Antigens, Bacterial / chemistry
  • Antigens, Bacterial / genetics*
  • Antigens, Bacterial / immunology*
  • BCG Vaccine / immunology
  • Clinical Trials as Topic
  • Computational Biology / methods
  • Drug Design
  • Humans
  • Mycobacterium tuberculosis / immunology*
  • Tuberculosis / prevention & control*
  • Tuberculosis Vaccines / administration & dosage
  • Tuberculosis Vaccines / immunology*
  • Vaccines, Subunit / genetics
  • Vaccines, Subunit / immunology*
  • Vaccines, Subunit / standards

Substances

  • Antigens, Bacterial
  • BCG Vaccine
  • Tuberculosis Vaccines
  • Vaccines, Subunit