Cytotoxic pimarane-type diterpenes from the marine sediment-derived fungus Eutypella sp. FS46

Nat Prod Res. 2017 Feb;31(4):404-410. doi: 10.1080/14786419.2016.1169418. Epub 2016 Apr 6.

Abstract

Two new pimarane-type diterpenes, scopararanes H-I (1-2), along with five known ones (3-7) were isolated from the culture broth of a marine sediment-derived fungus Eutypella sp. FS46, which was obtained from the South China Sea. Their structures were established by extensive spectroscopic analysis. All of them were evaluated for their cytotoxic activities against MCF-7, NCI-H460 and SF-268 tumour cell lines. Scopararane I (2) showed moderate inhibitory activities.

Keywords: Eutypella sp. FS46; cytotoxic activity; pimarane diterpenes; scopararane H; scopararane I.

MeSH terms

  • Abietanes / chemistry
  • Abietanes / isolation & purification*
  • Abietanes / pharmacology
  • Antineoplastic Agents / isolation & purification*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Fermentation
  • Geologic Sediments / microbiology*
  • Humans
  • Xylariales / metabolism*

Substances

  • Abietanes
  • Antineoplastic Agents
  • pimarane