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, 32 (6), 320-321

Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing


Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing

Ian A Roundtree et al. Trends Genet.


N(6)-Methyladenosine (m(6)A) is emerging as a chemical mark that broadly affects the flow of genetic information in various biological processes in eukaryotes. Recently, Xiao et al. reported that the nuclear m(6)A reader protein YTHDC1 impacts mRNA splicing, providing a transcriptome-wide glance of splicing changes affected by this mRNA methylation reader protein.

Keywords: N(6)-methyladenosine; YTHDC1; mRNA splicing.

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  • Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.
    Xiao W, Adhikari S, Dahal U, Chen YS, Hao YJ, Sun BF, Sun HY, Li A, Ping XL, Lai WY, Wang X, Ma HL, Huang CM, Yang Y, Huang N, Jiang GB, Wang HL, Zhou Q, Wang XJ, Zhao YL, Yang YG. Xiao W, et al. Mol Cell. 2016 Feb 18;61(4):507-519. doi: 10.1016/j.molcel.2016.01.012. Epub 2016 Feb 11. Mol Cell. 2016. PMID: 26876937

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