Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs

J Vet Sci. 2016 Mar;17(1):111-3. doi: 10.4142/jvs.2016.17.1.111. Epub 2016 Mar 22.

Abstract

To assess the effects of a single supraphysiological postnatal administration of a progestogen on uterine glands in dogs, 10 females were randomly assigned to a medroxyprogesterone acetate 35 mg (MPA; n = 6) or placebo (n = 4) group within the first 24 h of birth. The safety of the treatment was also evaluated. A transient mild clitoris enlargement appeared in MPA-treated females. Microscopic postpubertal uterine assessment revealed the presence of uterine glands in all cases without significant differences in the area occupied by the glands per µm(2) of endometrium nor in the height of the uterine epithelium.

Keywords: canid; contraception; endocrine disruption; genital tract; neonatal.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Clitoris / drug effects
  • Dogs
  • Epithelium / drug effects*
  • Female
  • Medroxyprogesterone Acetate / pharmacology*
  • Organ Size / drug effects
  • Random Allocation
  • Sexual Maturation / drug effects
  • Uterus / drug effects*

Substances

  • Medroxyprogesterone Acetate