Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Feb 18;5:72-8.
doi: 10.1016/j.bbacli.2016.02.003. eCollection 2016 Jun.

Reduced Inflammatory and Muscle Damage Biomarkers Following Oral Supplementation With Bioavailable Curcumin

Affiliations
Free PMC article

Reduced Inflammatory and Muscle Damage Biomarkers Following Oral Supplementation With Bioavailable Curcumin

Brian K McFarlin et al. BBA Clin. .
Free PMC article

Abstract

Background: Exercise-Induced Muscle Damage (EIMD) and delayed onset muscle soreness (DOMS) impact subsequent training sessions and activities of daily living (ADL) even in active individuals. In sedentary or diseased individuals, EIMD and DOMS may be even more pronounced and present even in the absence of structured exercise.

Methods: The purpose of this study was to determine the effects of oral curcumin supplementation (Longvida® 400 mg/days) on muscle & ADL soreness, creatine kinase (CK), and inflammatory cytokines (TNF-α, IL-6, IL-8, IL-10) following EMID (eccentric-only dual-leg press exercise). Subjects (N = 28) were randomly assigned to either curcumin (400 mg/day) or placebo (rice flour) and supplemented 2 days before to 4 days after EMID. Blood samples were collected prior to (PRE), and 1, 2, 3, and 4 days after EIMD to measure CK and inflammatory cytokines. Data were analyzed by ANOVA with P < 0.05.

Results: Curcumin supplementation resulted in significantly smaller increases in CK (- 48%), TNF-α (- 25%), and IL-8 (- 21%) following EIMD compared to placebo. We observed no significant differences in IL-6, IL-10, or quadriceps muscle soreness between conditions for this sample size.

Conclusions: Collectively, the findings demonstrated that consumption of curcumin reduced biological inflammation, but not quadriceps muscle soreness, during recovery after EIMD. The observed improvements in biological inflammation may translate to faster recovery and improved functional capacity during subsequent exercise sessions.

General significance: These findings support the use of oral curcumin supplementation to reduce the symptoms of EIMD. The next logical step is to evaluate further the efficacy of an inflammatory clinical disease model.

Keywords: Cytokines; Inflammation; Leg press; Multiplex.

Figures

Fig. 1
Fig. 1
Subjective quadriceps muscle and ADL soreness was consistently used to assess perceived muscle soreness using a visual analog scale. Measurements were made prior to (PRE), 1, 2, 3, and 4 days following EIMD (Exercise-Induced Muscle Damage; 60 reps at 110% of the 1RM, eccentric only). Black bars represent placebo and gray bars represent curcumin. Summated right (A), left (B), and combined (C) quadriceps soreness was assessed. Also ADL soreness (D) was assessed using a standard scale. † indicated leg with a significant (P < 0.05) increase from PRE across both groups at 1, 2, and 3 days following EMID. There was no significant difference in muscle soreness between treatment conditions.
Fig. 2
Fig. 2
Serum creatine kinase (CK) measured prior to (PRE), 1, 2, 3, and 4 days following EIMD (Exercise-Induced Muscle Damage; 60 reps at 110% of the 1RM, eccentric only). Black bars represent placebo and gray bars represent curcumin. * indicated a difference between curcumin and placebo groups (P < 0.05).
Fig. 3
Fig. 3
Serum cytokines (IL-8 (A), TNF-α (B), IL-6 (C), and IL-10 (D)) measured prior to (PRE), 1, 2, 3, and 4 days following EIMD (Exercise-Induced Muscle Damage; 60 reps at 110% of the 1RM, eccentric only). Black bars represent placebo and gray bars represent curcumin. * indicated a significant difference between curcumin and placebo groups (P < 0.05).
Fig. 4
Fig. 4
Heat map for global changes. A standard heat map was generated using a green (smallest response) to red (largest response) color scale to graphically represent each biomarker change (i.e. CK, TNF-α, etc.) as a function of treatment condition (curcumin vs. placebo). The included scale demonstrates the full range of responses. Measurements were made prior to (PRE), 1, 2, 3, and 4 days following EIMD (Exercise-Induced Muscle Damage; 60 reps at 110% of the 1RM, eccentric only). This figure demonstrates that curcumin treatment was associated with a muted response for serum cytokines (IL-6, IL-8, IL-10, and TNF-α) and creatine kinase (CK). Further interpretation reveals that while not significant at this sample size, the muscle soreness response for curcumin treatment matches with the inflammation biomarkers, particularly at 1 and 2 days. Globally this figure illustrates the close relationship between the biomarkers used in this study to evaluate recovery following EIMD.

Similar articles

See all similar articles

Cited by 13 articles

See all "Cited by" articles

References

    1. Auriel E., Regev K., Korczyn A.D. Nonsteroidal anti-inflammatory drugs exposure and the central nervous system. Handb. Clin. Neurol. 2014;119:577–584. - PubMed
    1. Breslin W.L., Johnston C.A., Strohacker K., Carpenter K.C., Davidson T.R., Moreno J.P., Foreyt J.P., McFarlin B.K. Obese Mexican American children have elevated MCP-1, TNF-alpha, monocyte concentration, and dyslipidemia. Pediatrics. 2012;129(5):e1180–e1186. - PubMed
    1. Cai X., Fang Z., Dou J., Yu A., Zhai G. Bioavailability of quercetin: problems and promises. Curr. Med. Chem. 2013;20(20):2572–2582. - PubMed
    1. Chun K.S., Keum Y.S., Han S.S., Song Y.S., Kim S.H., Surh Y.J. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. Carcinogenesis. 2003;24(9):1515–1524. - PubMed
    1. Close G.L., Ashton T., Cable T., Doran D., Noyes C., McArdle F., MacLaren D.P. Effects of dietary carbohydrate on delayed onset muscle soreness and reactive oxygen species after contraction induced muscle damage. Br. J. Sports Med. 2005;39(12):948–953. - PMC - PubMed

LinkOut - more resources

Feedback