Sinonasal inverted papilloma: From diagnosis to treatment

Eur Ann Otorhinolaryngol Head Neck Dis. 2016 Nov;133(5):337-341. doi: 10.1016/j.anorl.2016.03.006. Epub 2016 Apr 1.


Inverted papilloma is a rare sinonasal tumor that mainly occurs in adults during the 5th decade. Three characteristics make this tumor very different from other sinonasal tumors: a relatively strong potential for local destruction, high rate of recurrence, and a risk of carcinomatous evolution. Etiology remains little understood, but an association with human papilloma virus has been reported in up to 40% of cases, raising the suspicions of implication in the pathogenesis of inverted papilloma. Treatment of choice is surgery, by endonasal endoscopic or external approach, depending on extension and tumoral characteristics. Follow-up is critical, to diagnose local relapse, which is often early but may also be late. The seriousness of this pathology lies in its association with carcinoma, which may be diagnosed at the outset or at recurrence during follow-up. It is important to diagnose recurrence to enable early treatment, especially in case of associated carcinoma or malignancy. A comprehensive review of the international literature was performed on PubMed and Embase, using the following search-terms: "sinonasal" [All Fields] AND ("papilloma, inverted" [MeSH Terms] OR ("papilloma" [All Fields] AND "inverted" [All Fields]) OR "inverted papilloma" [All Fields] OR ("inverted" [All Fields] AND "papilloma" [All Fields])). We reviewed all articles referring to sinonasal inverted papilloma published up to January 2015. The present article updates the state of knowledge regarding sinonasal inverted papilloma.

Keywords: Endonasal endoscopic surgery; HPV; Inverted papilloma; Sinonasal tumor; Squamous cell carcinoma.

Publication types

  • Review

MeSH terms

  • Diagnostic Imaging
  • Endoscopy
  • Humans
  • Neoplasm Recurrence, Local
  • Nose Neoplasms / diagnosis*
  • Nose Neoplasms / etiology
  • Nose Neoplasms / surgery*
  • Papilloma, Inverted / diagnosis*
  • Papilloma, Inverted / etiology
  • Papilloma, Inverted / surgery*
  • Papillomaviridae / pathogenicity
  • Paranasal Sinus Neoplasms / diagnosis*
  • Paranasal Sinus Neoplasms / etiology
  • Paranasal Sinus Neoplasms / surgery*
  • Rare Diseases