Durability of prostheses for transcatheter aortic valve implantation

Nat Rev Cardiol. 2016 Jun;13(6):360-7. doi: 10.1038/nrcardio.2016.43. Epub 2016 Apr 7.


Transcatheter aortic valve implantation (TAVI) has become the standard of care for inoperable patients, and the preferred treatment option for high-risk patients with severe aortic stenosis. Given that this therapy was intended for elderly patients with limited life expectancy, long-term durability has not been in the focus. Now that TAVI is increasingly being used in patients with intermediate-risk and lower-risk profiles, device durability has gained importance. The available mid-term results for TAVI are promising; however, little is known about the fate of TAVI devices beyond 5 years. The experience with long-term durability of surgical valves shows that ≥10-year follow-up is required to ensure reliable durability data. In this Review, we discuss the existing studies of TAVI durability, highlight differences between surgical and transcatheter treatment of aortic stenosis that might influence durability, and present a clinical solution for failed prostheses. Furthermore, we suggest how device durability might influence the future selection of patients for TAVI.

Publication types

  • Review

MeSH terms

  • Aged
  • Aortic Valve / surgery
  • Aortic Valve Stenosis / surgery*
  • Heart Valve Prosthesis Implantation
  • Heart Valve Prosthesis*
  • Humans
  • Prosthesis Design
  • Prosthesis Failure*
  • Risk Factors
  • Time Factors
  • Transcatheter Aortic Valve Replacement / instrumentation*
  • Transplantation, Heterologous