Structural ECM components in the premetastatic and metastatic niche

Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C955-67. doi: 10.1152/ajpcell.00326.2015. Epub 2016 Apr 6.


The aim of this review is to give an overview of the extracellular matrix (ECM) components that are important for creating structural changes in the premetastatic and metastatic niche. The successful arrival and survival of cancer cells that have left the primary tumor and colonized distant sites depends on the new microenvironment they encounter. The primary tumor itself releases factors into the circulation that travel to distant organs and then initiate structural changes, both non-enzymatic and enzymatic, to create a favorable niche for the disseminating tumor cells. Therapeutic strategies aimed at targeting cell-ECM interactions may well be one of the best viable approaches to combat metastasis and thus improve patient care.

Keywords: ECM; matrisome; metastatic; niche; premetastatic.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Movement*
  • Cell Proliferation
  • Cell Survival
  • Exosomes / metabolism
  • Exosomes / pathology
  • Extracellular Matrix Proteins / genetics
  • Extracellular Matrix Proteins / metabolism*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Neoplastic Cells, Circulating / metabolism*
  • Neoplastic Cells, Circulating / pathology
  • Signal Transduction
  • Transcriptome
  • Tumor Hypoxia
  • Tumor Microenvironment*


  • Extracellular Matrix Proteins