Membrane Lipids in Presynaptic Function and Disease

Elsa Lauwers; Rose Goodchild; Patrik Verstreken

doi:10.1016/j.neuron.2016.02.033

Membrane Lipids in Presynaptic Function and Disease

Neuron. 2016 Apr 6;90(1):11-25. doi: 10.1016/j.neuron.2016.02.033.

Authors

Elsa Lauwers¹, Rose Goodchild², Patrik Verstreken³

Affiliations

¹ Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium; VIB Center for the Biology of Disease, Leuven Institute for Neurodegenerative Disease, Herestraat 49, Bus 602, 3000 Leuven, Belgium. Electronic address: elsa.lauwers@cme.vib-kuleuven.be.
² Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium; VIB Center for the Biology of Disease, Leuven Institute for Neurodegenerative Disease, Herestraat 49, Bus 602, 3000 Leuven, Belgium. Electronic address: rose.goodchild@cme.vib-kuleuven.be.
³ Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium; VIB Center for the Biology of Disease, Leuven Institute for Neurodegenerative Disease, Herestraat 49, Bus 602, 3000 Leuven, Belgium. Electronic address: patrik.verstreken@cme.vib-kuleuven.be.

PMID: 27054615
DOI: 10.1016/j.neuron.2016.02.033

Abstract

Lipids are the most abundant organic compounds in the brain. The brain has a unique lipidome, and changes in lipid concentration, organization, and metabolism are associated with many neuronal diseases. Here, we discuss recent advances in understanding presynaptic membrane lipid organization, centered on illustrative examples of how the lipids themselves regulate membrane trafficking and control protein activity. This insight highlights that presynaptic terminals are membrane-remodeling machines and that cooperation between lipid and protein molecules underlies presynaptic activity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bipolar Disorder / genetics
Bipolar Disorder / metabolism
Endocytosis
Exocytosis
Humans
Ion Channels / metabolism
Lipid Metabolism / genetics
Membrane Lipids / metabolism*
Membrane Proteins / metabolism*
Neurotransmitter Agents / metabolism*
Parkinson Disease / genetics
Parkinson Disease / metabolism
Phosphatidylinositols / metabolism
Presynaptic Terminals / metabolism*
Protein Transport*
SNARE Proteins / metabolism
Schizophrenia / genetics
Schizophrenia / metabolism
Synaptic Transmission*
Synaptic Vesicles / metabolism*

Substances

Ion Channels
Membrane Lipids
Membrane Proteins
Neurotransmitter Agents
Phosphatidylinositols
SNARE Proteins