The genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives

Am J Med Genet. 1989 Jan;32(1):105-8. doi: 10.1002/ajmg.1320320122.


We have analysed the pedigrees of 265 probands with Crohn disease, collected from a specialty clinic at the University of Düsseldorf. Complex segregation analysis suggests the presence of a recessive gene with incomplete penetrance for susceptibility to the disease with no residual causes of family resemblance. However, a proportion of the isolated cases are probably due to phenocopies, this proportion being greatest among cases with an advanced age of onset.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • Crohn Disease / genetics*
  • Female
  • Gene Frequency
  • Genes, Recessive*
  • Germany, West
  • Humans
  • Male
  • Models, Genetic
  • Pedigree
  • Phenotype