Fibrous Dysplasia Presenting as a Cold Spot in 18F-FLT PET/CT Imaging

Clin Nucl Med. 2016 Jun;41(6):510-1. doi: 10.1097/RLU.0000000000001209.


Fibrous dysplasia (FD) is a benign bone lesion in which normal bone marrow is replaced by fibro-osseous tissue. The usual high fluorodeoxyglucose (F-FDG) uptake in FD may lead to the misdiagnosis of bone malignancy. Herein, we describe the case of a 42-year old man with histologically verified FD of the pubic bone, which has been subsequently examined during follow-up for rectal cancer, using both F-FDG and fluorothymidine (F-FLT) PET/CT imaging. The FD lesion was characterized by a high uptake of F-FDG (hot spot) but very low uptake of F-FLT (cold spot) as compared with the contralateral unaffected pubic bone.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Dideoxynucleosides
  • Fibrous Dysplasia of Bone / diagnostic imaging*
  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Positron Emission Tomography Computed Tomography
  • Pubic Bone / diagnostic imaging*
  • Radiopharmaceuticals


  • Dideoxynucleosides
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • alovudine