Rice bran oil and canola oil improve blood lipids compared to sunflower oil in women with type 2 diabetes: A randomized, single-blind, controlled trial

J Clin Lipidol. 2016 Mar-Apr;10(2):299-305. doi: 10.1016/j.jacl.2015.11.016. Epub 2015 Dec 7.


Background: Hypolipidemic effects of vegetable oils have been demonstrated in a number of studies, but there is no study, which compares the effects of canola oil (CO) and rice bran oil (RBO) on diabetic patient. We aimed to compare the effects of CO and RBO consumption on blood lipids in women with type 2 diabetes.

Methods: Seventy-five postmenopausal women with type 2 diabetes participated in this single-center, randomized, controlled, parallel-group trial in Shiraz, Iran. Participants were randomly allocated to three groups including a control group (balance diet + 30 g/d sunflower oil) and two intervention groups (balance diet + 30 g/day CO or RBO). At baseline and after 8 weeks, serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured.

Results: At 8 weeks, mean of serum levels of TG (mg/dL), TC (mg/dL), and LDL-C (mg/dL) significantly decreased in the CO group (-23.66, P < .001; -11.92, P < .001; and -6.33, P = .013, respectively) and RBO group (-38.62, P < .001; -17.25, P < .001; and -8.90, P = .002, respectively) compared with the controls (7.01, 4.06, and 2.90, respectively). Also, in comparison with CO group, the changes of TG, LDL-C, and non-HDL-C levels were significantly more in the RBO group (P = .007, P = .012, and P = .011, respectively). Levels of serum HDL-C remained unchanged in all groups at the end of study.

Conclusions: Substitution of RBO or CO for sunflower oil could attenuate lipid disorders in type 2 diabetes women. Moreover, RBO could improve lipid profile more efficiently than CO.

Keywords: Canola oil; Lipid profile; Rice bran oil; Type 2 diabetes.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diabetes Mellitus, Type 2 / blood*
  • Diet
  • Fatty Acids, Monounsaturated / pharmacology*
  • Female
  • Humans
  • Lipids / blood*
  • Middle Aged
  • Plant Oils / pharmacology*
  • Rapeseed Oil
  • Rice Bran Oil
  • Single-Blind Method
  • Sunflower Oil


  • Fatty Acids, Monounsaturated
  • Lipids
  • Plant Oils
  • Rapeseed Oil
  • Sunflower Oil
  • Rice Bran Oil

Associated data

  • IRCT/IRCT2014050417568N1