Metformin-Induced Fixed-Drug Eruption Confirmed by Multiple Exposures

Am J Case Rep. 2016 Apr 8:17:231-4. doi: 10.12659/ajcr.896424.


Background: A fixed-drug eruption (FDE) is a reaction characterized by cutaneous lesions that appear due to exposure to a particular drug. Barbiturates, carbamazepine, sulfamethoxazole, and tetracyclines have all been associated with causation of FDEs. Although these drugs are more commonly associated with FDEs, any introduction of a medication has the potential to result in a FDE. Metformin, a commonly used medication to improve glycemic control, has been reported to cause dermatologic reactions in some case reports, but only a single previously documented case report discusses the potential of metformin-associated FDE.

Case report: We describe a 56-year-old woman who developed a FDE with multiple exposures to metformin. Upon each exposure, small, round, erythematic lesions developed on the palms of the hands and soles of the feet; these lesions resolved each time after discontinuation of metformin. According to the Naranjo scale, there is a definite association between metformin and FDE in this case (score of 8).

Conclusions: This report contributes to the limited documented literature on metformin-induced FDE. Clinicians should be made aware of possible FDEs associated with this commonly used medication.

Publication types

  • Case Reports

MeSH terms

  • Diabetes Mellitus, Type 2 / drug therapy
  • Drug Eruptions / etiology*
  • Female
  • Humans
  • Hypoglycemic Agents / adverse effects*
  • Metformin / adverse effects*
  • Middle Aged


  • Hypoglycemic Agents
  • Metformin