Synthesis of 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles by the reaction of indoline-2,3-diones with difluoromethylene phosphabetaine

Chem Commun (Camb). 2016 May 1;52(35):5969-72. doi: 10.1039/c6cc00666c. Epub 2016 Apr 8.

Abstract

An unprecedent reaction of indoline-2,3-diones and (triphenylphosphonio)difluoroacetate (PDFA) afforded novel 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles in moderate to excellent yields. These products could be transformed into other trifluoromethylated oxindole derivatives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Betaine / analogs & derivatives*
  • Betaine / chemistry
  • Catalysis
  • Chemistry Techniques, Synthetic
  • Indoles / chemical synthesis*
  • Indoles / chemistry*
  • Oxindoles

Substances

  • Indoles
  • Oxindoles
  • difluoromethylene phosphabetaine
  • indoline-2,3-dione
  • 2-oxindole
  • Betaine