Toxic Epidermal Necrolysis with Gastrointestinal Involvement: A Case Report and Review of the Literature

J Burn Care Res. 2017 Jan/Feb;38(1):e450-e455. doi: 10.1097/BCR.0000000000000336.


Gastrointestinal involvement is a rare complication of toxic epidermal necrolysis syndrome (TENS) that results in sloughing of the intestinal epithelium. Prior case reports have noted the potential susceptibility of the entire gastrointestinal tract, from oropharynx and esophagus to sigmoid colon and rectum. Given its infrequency, the effect of gastrointestinal involvement on the treatment and prognosis of TENS is poorly understood. Here, the authors report a case of gastrointestinal symptoms in a patient diagnosed with toxic epidermal necrolysis, likely representing gastrointestinal involvement. In addition, the authors describe the histopathologic and endoscopic characteristics of the involved mucosa, clinical course, and present a review of the literature of this rare but potentially impactful complication of TENS.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Allopurinol / therapeutic use
  • Female
  • Gastrointestinal Diseases / diagnosis*
  • Gastrointestinal Diseases / etiology
  • Gastrointestinal Diseases / therapy*
  • Gout / complications
  • Gout / drug therapy
  • Gout Suppressants / therapeutic use
  • Humans
  • Stevens-Johnson Syndrome / complications
  • Stevens-Johnson Syndrome / diagnosis*
  • Stevens-Johnson Syndrome / therapy*


  • Gout Suppressants
  • Allopurinol