A Time Bomb for Leukemia

Cell. 2016 Apr 7;165(2):262-3. doi: 10.1016/j.cell.2016.03.024.


Alterations of the circadian clock have been linked to cancer development. Puram et al. (in this issue) now uncover differential requirements between healthy hematopoietic and diseased leukemic stem cells for core circadian transcription factors, wherein leukemic cells depend on the clock machinery for survival and growth.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Bombs
  • Circadian Clocks
  • Circadian Rhythm*
  • Humans
  • Leukemia
  • Transcription Factors*


  • Transcription Factors