The association of posterior capsular lens opacities with bilateral acoustic neuromas in patients with neurofibromatosis type 2

Arch Ophthalmol. 1989 Apr;107(4):541-4. doi: 10.1001/archopht.1989.01070010555030.


This study of 47 patients from 11 families with neurofibromatosis type 2 (NF 2) confirms our previously reported association between posterior capsular cataract and NF 2. A highly significant statistical association was found between the presence of posterior capsular lens opacities and the presence of NF 2 as determined by magnetic resonance imaging or pathologic diagnosis. This association was not present for other types of lens opacities that could be the result of age-related or nonspecific changes. When considering the diagnosis of NF 2, this finding now makes it essential to use a careful dilated biomicroscopic examination of the lens to evaluate known, suspected, or at-risk individuals for this potentially early associated manifestation.

MeSH terms

  • Cataract / complications*
  • Cataract / diagnosis
  • Cataract / pathology
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Neuroma, Acoustic / complications*
  • Neuroma, Acoustic / diagnosis
  • Neuroma, Acoustic / genetics
  • Pedigree
  • Photography