DNA Methylation of ADME Genes

Clin Pharmacol Ther. 2016 May;99(5):512-27. doi: 10.1002/cpt.343. Epub 2016 Feb 19.


The epigenetic regulation of expression of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs contributes to interindividual variability in drug response. Epigenetic mechanisms include DNA methylation, histone modifications, and miRNAs. This review systematically outlines the influence of DNA methylation on ADME gene expression and highlights the consequences for interindividual variability in drug response or drug-induced toxicity and the implications for personalized medicine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA Methylation / genetics*
  • Drug-Related Side Effects and Adverse Reactions / genetics
  • Epigenesis, Genetic / genetics*
  • Gene Expression Regulation
  • Histones / genetics
  • Humans
  • MicroRNAs / genetics
  • Pharmaceutical Preparations / metabolism
  • Pharmacokinetics*
  • Precision Medicine


  • Histones
  • MicroRNAs
  • Pharmaceutical Preparations