The role of Candida albicans in the severity of multiple sclerosis

Mycoses. 2016 Nov;59(11):697-704. doi: 10.1111/myc.12489.


The purpose of this study was to compare the specific activity of proteinase A in Candida albicans (C. albicans) between multiple sclerosis (MS) patients and controls. A total of 135 and 100 C. albicans strains were isolated from superficial surfaces of MS patients and healthy controls. Analytical models (regression and neural network) were applied to predict the severity of MS considering specific enzyme activity (SEA) and other factors which affect the expanded disability status scale (EDSS). The SEA of C. albicans in MS patients (3466.95 ± 277.25 μmol min-1 mg-1 ) was significantly more than that of healthy controls (1108.98 ± 294.51 μmol min-1 mg-1 ) that was confirmed by regression model (P < 0.001). The SEA had a positive correlation with the severity of MS (P < 0.001, r = 0.65). Analytical models showed that SEA played the most important role (among all included factors that affect on EDSS) in the severity of MS. The SEA of C. albicans in MS patients was significantly more than the healthy controls. The results suggest that the level of SEA of proteinase A and probably the capacity of C. albicans isolates to invade the host tissue is associated with the severity of MS.

Keywords: Candida albicans; Multiple sclerosis; expanded disability status scale; subtypes.

MeSH terms

  • Adult
  • Aspartic Acid Endopeptidases / metabolism*
  • Candida albicans / classification
  • Candida albicans / enzymology*
  • Candida albicans / isolation & purification*
  • Candida albicans / physiology
  • Female
  • Humans
  • Male
  • Multiple Sclerosis / microbiology*
  • Multiple Sclerosis / physiopathology*
  • Nails / microbiology
  • Neural Networks, Computer
  • Regression Analysis
  • Severity of Illness Index*
  • Skin / microbiology
  • Vagina / microbiology


  • Aspartic Acid Endopeptidases
  • aspergillopepsin II