Does vitamin D deficiency trigger carpal tunnel syndrome?

J Back Musculoskelet Rehabil. 2016 Nov 21;29(4):835-839. doi: 10.3233/BMR-160696.


Objective: Vitamin D deficiencies are associated with a variety of chronic diseases. The goal of the present study was to investigate the relationship between vitamin D levels and carpal tunnel syndrome (CTS).

Methods: This study included 90 patients with mild to moderate CTS and assessed their routine serum 25-hydroxyvitamin D levels. Additionally, the pain level of each subject was evaluated using the Visual Analogue Scale and the Douleur Neuropathique 4 Questionnaire (DN4).

Results: The severity levels of CTS were at a 75% mild level in the vitamin D deficiency group and a 47.1% mild level in the vitamin D normal group, with a significant difference between groups (p = 0.008). Correlation analyses revealed positive correlations between body mass index and DN4 scores (r = 0.499, p = 0.025) and between vitamin D levels and CTS severity (r = 0.364, p = 0.004) in the vitamin D deficiency group.

Conclusions: The present findings demonstrated that CTS may be triggered by vitamin D deficiency, and that the severity of CTS was correlated with vitamin D levels in the deficiency group. Additionally, there was a correlation between weight gain and neuropathic pain intensity in CTS patients with vitamin D deficiency. The present findings indicate that vitamin D levels should be assessed in CTS patients.

Keywords: 25-Dihydroxyvitamin; carpal tunnel syndrome; neuropathic pain.

MeSH terms

  • Carpal Tunnel Syndrome / etiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuralgia / complications
  • Severity of Illness Index
  • Visual Analog Scale
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D Deficiency / complications*
  • Weight Gain


  • Vitamin D
  • 25-hydroxyvitamin D