Linking pattern completion in the hippocampus to predictive coding in visual cortex

Nat Neurosci. 2016 May;19(5):665-667. doi: 10.1038/nn.4284. Epub 2016 Apr 11.


Models of predictive coding frame perception as a generative process in which expectations constrain sensory representations. These models account for expectations about how a stimulus will move or change from moment to moment, but do not address expectations about what other, distinct stimuli are likely to appear based on prior experience. We show that such memory-based expectations in human visual cortex are related to the hippocampal mechanism of pattern completion.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Hippocampus / physiology*
  • Humans
  • Male
  • Memory
  • Photic Stimulation
  • Visual Cortex / physiology*
  • Visual Perception / physiology*
  • Young Adult